Models of Abnormal Scarring

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Models of Abnormal Scarring

Keloids and hypertrophic scars are thick, raised dermal scars, caused by derailing of the normal scarring process. Extensive research on such abnormal scarring has been done; however, these being refractory disorders specific to humans, it has been difficult to establish a universal animal model. A wide variety of animal models have been used. These include the athymic mouse, rats, rabbits, and...

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Abnormal scarring with keloid formation after osteochondroma excision in children with multiple hereditary exostoses.

INTRODUCTION Multiple hereditary exostoses (MHE) is an autosomal dominant condition characterized by numerous cartilage-capped exostoses/osteochondromas in areas of actively growing bone. Abnormal scarring with keloid formation after osteochondroma excision in children with MHE has not been previously described. METHODS A retrospective double-cohort study was undertaken to determine if childr...

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Mechanobiology of scarring.

The mechanophysiological conditions of injured skin greatly influence the degree of scar formation, scar contracture, and abnormal scar progression/generation (e.g., keloids and hypertrophic scars). It is important that scar mechanobiology be understood from the perspective of the extracellular matrix and extracellular fluid, in order to analyze mechanotransduction pathways and develop new stra...

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Business Model Shocks and Abnormal Accrual Models

Economics challenge the specification of discretionary accrual models. Since rent seeking firms pursue differentiated business strategies, firms in the same industry have heterogeneous accrual generating processes. Moreover, Schumpeter’s “creative destruction” forces existing firms to revise their extant business models. We present evidence that such business model shocks are widespread, propag...

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Removing moles? Scarring?

Most dermatologists can perform cosmetic mole removals (this is not something to try at home with your trusty disposable razor). To take off an elevated mole, a dermatologist numbs the area with local anesthetic and then shaves off the raised section of the mole with a sterile scalpel. The healing process usually leaves a flat scar that's somewhat lighter than the rest of your skin. Sometimes t...

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ژورنال

عنوان ژورنال: BioMed Research International

سال: 2013

ISSN: 2314-6133,2314-6141

DOI: 10.1155/2013/423147